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CRISPR-Cas orthologues and variants: optimizing the repertoire, specificity and delivery of genome engineering tools
Robust and cost-effective genome editing in a diverse array of cells and model organisms is now possible thanks to the discovery of the RNA-guided endonucleases of the CRISPR-Cas system. The commonly used Cas9 of Streptococcus pyogenes shows high levels of activity but, depending on the application,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569134/ https://www.ncbi.nlm.nih.gov/pubmed/28634692 http://dx.doi.org/10.1007/s00335-017-9697-4 |