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CRISPR-Cas orthologues and variants: optimizing the repertoire, specificity and delivery of genome engineering tools

Robust and cost-effective genome editing in a diverse array of cells and model organisms is now possible thanks to the discovery of the RNA-guided endonucleases of the CRISPR-Cas system. The commonly used Cas9 of Streptococcus pyogenes shows high levels of activity but, depending on the application,...

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Detalles Bibliográficos
Autores principales: Cebrian-Serrano, Alberto, Davies, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569134/
https://www.ncbi.nlm.nih.gov/pubmed/28634692
http://dx.doi.org/10.1007/s00335-017-9697-4

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