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Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes

The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing. In vertebrates, H2A.Z has two hypervariants, H2A.Z.1 and H2A.Z.2, that have almost identical sequences except...

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Detalles Bibliográficos
Autores principales: Dunn, Carissa J., Sarkar, Pushpita, Bailey, Emma R., Farris, Shannon, Zhao, Meilan, Ward, James M., Dudek, Serena M., Saha, Ramendra N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569379/
https://www.ncbi.nlm.nih.gov/pubmed/28856239
http://dx.doi.org/10.1523/ENEURO.0040-17.2017