Restoration of correct splicing in IVSI-110 mutation of β-globin gene with antisense oligonucleotides: implications and applications in functional assay development

OBJECTIVE(S): The use of antisense oligonucleotides (AOs) to restore normal splicing by blocking the recognition of aberrant splice sites by the spliceosome represents an innovative means of potentially controlling certain inherited disorders affected by aberrant splicing. Selection of the appropria...

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Detalles Bibliográficos
Autores principales: Derakhshan, Sima Mansoori, Khaniani, Mahmoud Shekari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569442/
https://www.ncbi.nlm.nih.gov/pubmed/28868125
http://dx.doi.org/10.22038/IJBMS.2017.8840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569442/
https://www.ncbi.nlm.nih.gov/pubmed/28868125
http://dx.doi.org/10.22038/IJBMS.2017.8840

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