Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice

BACKGROUND: A subset of osteoarthritis (OA) patients experience joint pain with neuropathic characteristics. Mediators such as neutrophil elastase, a serine proteinase, may be released during acute OA inflammatory flares. We have previously shown that local administration of neutrophil elastase caus...

Descripción completa

Detalles Bibliográficos
Autores principales: Muley, Milind M., Krustev, Eugene, Reid, Allison R., McDougall, Jason J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569523/
https://www.ncbi.nlm.nih.gov/pubmed/28835277
http://dx.doi.org/10.1186/s12974-017-0944-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569523/
https://www.ncbi.nlm.nih.gov/pubmed/28835277
http://dx.doi.org/10.1186/s12974-017-0944-0

Ejemplares similares