NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein

Nijmegen breakage syndrome (NBS), a condition similar to Ataxia-Telangiectasia (A-T), is a radiation-hypersensitive genetic disorder showing chromosomal instability, radio-resistant DNA synthesis, immunodeficiency, and predisposition to malignances. The product of the responsible gene, NBS1, forms a...

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Detalles Bibliográficos
Autores principales: Zhou, Hui, Kawamura, Kasumi, Yanagihara, Hiromi, Kobayashi, Junya, Zhang-Akiyama, Qiu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570008/
https://www.ncbi.nlm.nih.gov/pubmed/28369484
http://dx.doi.org/10.1093/jrr/rrx014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570008/
https://www.ncbi.nlm.nih.gov/pubmed/28369484
http://dx.doi.org/10.1093/jrr/rrx014

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