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NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein

Nijmegen breakage syndrome (NBS), a condition similar to Ataxia-Telangiectasia (A-T), is a radiation-hypersensitive genetic disorder showing chromosomal instability, radio-resistant DNA synthesis, immunodeficiency, and predisposition to malignances. The product of the responsible gene, NBS1, forms a...

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Detalles Bibliográficos
Autores principales:	Zhou, Hui, Kawamura, Kasumi, Yanagihara, Hiromi, Kobayashi, Junya, Zhang-Akiyama, Qiu-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570008/ https://www.ncbi.nlm.nih.gov/pubmed/28369484 http://dx.doi.org/10.1093/jrr/rrx014

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