APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA

AID/APOBEC family enzymes are best known for deaminating cytosine bases to uracil in single-stranded DNA, with characteristic sequence preferences that can produce mutational signatures in targets such as retroviral and cancer cell genomes. These deaminases have also been proposed to function in DNA...

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Detalles Bibliográficos
Autores principales: Schutsky, Emily K., Nabel, Christopher S., Davis, Amy K. F., DeNizio, Jamie E., Kohli, Rahul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570014/
https://www.ncbi.nlm.nih.gov/pubmed/28472485
http://dx.doi.org/10.1093/nar/gkx345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570014/
https://www.ncbi.nlm.nih.gov/pubmed/28472485
http://dx.doi.org/10.1093/nar/gkx345

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