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Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m(6)A, m(5)C, m(3)U, and m(5)U by top-down mass spectrometry
Nucleobase methylations are ubiquitous posttranscriptional modifications of ribonucleic acids (RNA) that can substantially increase the structural diversity of RNA in a highly dynamic fashion with implications for gene expression and human disease. However, high throughput, deep sequencing does not...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570050/ https://www.ncbi.nlm.nih.gov/pubmed/28549193 http://dx.doi.org/10.1093/nar/gkx470 |