Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression

Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Koo, Taeyoung, Yoon, A-Rum, Cho, Hee-Yeon, Bae, Sangsu, Yun, Chae-Ok, Kim, Jin-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570104/
https://www.ncbi.nlm.nih.gov/pubmed/28575452
http://dx.doi.org/10.1093/nar/gkx490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570104/
https://www.ncbi.nlm.nih.gov/pubmed/28575452
http://dx.doi.org/10.1093/nar/gkx490

Ejemplares similares