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Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression
Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly inter...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570104/ https://www.ncbi.nlm.nih.gov/pubmed/28575452 http://dx.doi.org/10.1093/nar/gkx490 |