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ALK signaling cascade confers multiple advantages to glioblastoma cells through neovascularization and cell proliferation

Anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase, is essentially and transiently expressed in the developing nervous system. Here we examined the functional role of the ALK gene in glioblastomas (GBMs). In clinical samples of GBMs, high ALK expression without gene rearrangements...

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Detalles Bibliográficos
Autores principales: Chiba, Risako, Akiya, Masashi, Hashimura, Miki, Oguri, Yasuko, Inukai, Madoka, Hara, Atsuko, Saegusa, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570309/
https://www.ncbi.nlm.nih.gov/pubmed/28837676
http://dx.doi.org/10.1371/journal.pone.0183516