Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental clues and depend on highly plastic transcriptional...

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Detalles Bibliográficos
Autores principales: Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John S., Phadke, Tanushree, Gambert, Romain, Keller, Caroline Gubser, Ludwig, Marie-Gabrielle, Baumgarten, Birgit, Frederiksen, Mathias, Schübeler, Dirk, Seuwen, Klaus, Bouwmeester, Tewis, Fodor, Barna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570424/
https://www.ncbi.nlm.nih.gov/pubmed/28837623
http://dx.doi.org/10.1371/journal.pone.0183679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570424/
https://www.ncbi.nlm.nih.gov/pubmed/28837623
http://dx.doi.org/10.1371/journal.pone.0183679

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