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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...

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Autores principales: Wahl, Simone, Drong, Alexander, Lehne, Benjamin, Loh, Marie, Scott, William R, Kunze, Sonja, Tsai, Pei-Chien, Ried, Janina S, Zhang, Weihua, Yang, Youwen, Tan, Sili, Fiorito, Giovanni, Franke, Lude, Guarrera, Simonetta, Kasela, Silva, Kriebel, Jennifer, Richmond, Rebecca C, Adamo, Marco, Afzal, Uzma, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole, Apperley, Jane F, Beekman, Marian, Bertazzi, Pier Alberto, Black, S. Lucas, Blancher, Christine, Bonder, Marc-Jan, Brosch, Mario, Carstensen-Kirberg, Maren, De Craen, Anton J.M., de Lusignan, Simon, Dehghan, Abbas, Elkalaawy, Mohamed, Fischer, Krista, Franco, Oscar H., Gaunt, Tom R, Hampe, Jochen, Hashemi, Majid, Isaacs, Aaron, Jenkinson, Andrew, Jha, Sujeet, Kato, Norihiro, Krogh, Vittorio, Laffan, Michael, Meisinger, Christa, Meitinger, Thomas, Mok, Zuan Yu, Motta, Valeria, Ng, Hong Kiat, Nikolakopoulou, Zacharoula, Nteliopoulos, Georgios, Panico, Salvatore, Pervjakova, Natalia, Prokisch, Holger, Rathmann, Wolfgang, Roden, Michael, Rota, Federica, Rozario, Michelle Ann, Sandling, Johanna K, Schafmayer, Clemens, Schramm, Katharina, Siebert, Reiner, Slagboom, P Eline, Soininen, Pasi, Stolk, Lisette, Strauch, Konstantin, Tai, E-Shyong, Tarantini, Letizia, Thorand, Barbara, Tigchelaar, Ettje F, Tumino, Rosario, Uitterlinden, Andre G, van Duijn, Cornelia, van Meurs, Joyce BJ, Vineis, Paolo, Wickremasinghe, Ananda Rajitha, Wijmenga, Cisca, Yang, Tsun-Po, Yuan, Wei, Zhernakova, Alexandra, Batterham, Rachel L., Smith, George Davey, Deloukas, Panos, Heijmans, Bastiaan T, Herder, Christian, Hofman, Albert, Lindgren, Cecilia M, Milani, Lili, van der Harst, Pim, Peters, Annette, Illig, Thomas, Relton, Caroline L, Waldenberger, Melanie, Järvelin, Marjo-Riitta, Bollati, Valentina, Soong, Richie, Spector, Tim D, Scott, James, McCarthy, Mark I, Elliott, Paul, Bell, Jordana T, Matullo, Giuseppe, Gieger, Christian, Kooner, Jaspal S, Grallert, Harald, Chambers, John C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525/
https://www.ncbi.nlm.nih.gov/pubmed/28002404
http://dx.doi.org/10.1038/nature20784