Neonatal mouse hippocampus: Phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin (mTOR) signaling

BACKGROUND: Phlebotomy-induced anemia (PIA) is common in premature infants and affects neurodevelopment. PIA alters hippocampal metabolism in neonatal mice through tissue hypoxia and iron deficiency. The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., ox...

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Detalles Bibliográficos
Autores principales: Wallin, Diana J., Zamora, Tara G., Alexander, Michelle, Ennis, Kathleen M., Tran, Phu V., Georgieff, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570638/
https://www.ncbi.nlm.nih.gov/pubmed/28399115
http://dx.doi.org/10.1038/pr.2017.88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570638/
https://www.ncbi.nlm.nih.gov/pubmed/28399115
http://dx.doi.org/10.1038/pr.2017.88

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