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Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents

Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H(+)/Cl(−) cotransporters named ‘perenosins’. Here we report a new library of indole-based...

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Detalles Bibliográficos
Autores principales: Jowett, Laura A., Howe, Ethan N. W., Soto-Cerrato, Vanessa, Van Rossom, Wim, Pérez-Tomás, Ricardo, Gale, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570892/
https://www.ncbi.nlm.nih.gov/pubmed/28839192
http://dx.doi.org/10.1038/s41598-017-09645-9