Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does not bind to the C3a receptor and is indistinguishable from C3a using antibodies. Here we develop the most po...

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Detalles Bibliográficos
Autores principales: Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek, Fairlie, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570900/
https://www.ncbi.nlm.nih.gov/pubmed/28839129
http://dx.doi.org/10.1038/s41467-017-00414-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570900/
https://www.ncbi.nlm.nih.gov/pubmed/28839129
http://dx.doi.org/10.1038/s41467-017-00414-w

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