DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy

Type I epithelial ovarian cancer (EOC) is primarily resistant to platinum-based chemotherapies and needs novel therapeutics. Given the aberrant Wnt activation in type I EOC and the involvement of Dapper1 Antagonist of Catenin-1 (DACT1) in Wnt signalling, the role of DACT1 in tumourigenesis of type I...

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Detalles Bibliográficos
Autores principales: Li, Ruo-nan, Liu, Bin, Li, Xue-mei, Hou, Liang-si, Mu, Xiao-ling, Wang, Hui, Linghu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570946/
https://www.ncbi.nlm.nih.gov/pubmed/28839145
http://dx.doi.org/10.1038/s41598-017-08249-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570946/
https://www.ncbi.nlm.nih.gov/pubmed/28839145
http://dx.doi.org/10.1038/s41598-017-08249-7

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