The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin

The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) translocates its adenylate cyclase (AC) enzyme domain into target cells in a step that depends on membrane cholesterol content. We thus examined what role in toxin activities is played by the five putative cholesterol recognition amino acid...

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Detalles Bibliográficos
Autores principales: Masin, Jiri, Roderova, Jana, Osickova, Adriana, Novak, Petr, Bumba, Ladislav, Fiser, Radovan, Sebo, Peter, Osicka, Radim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571180/
https://www.ncbi.nlm.nih.gov/pubmed/28839199
http://dx.doi.org/10.1038/s41598-017-09575-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571180/
https://www.ncbi.nlm.nih.gov/pubmed/28839199
http://dx.doi.org/10.1038/s41598-017-09575-6

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