Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers

The artemether-lumefantrine combination requires food intake for the optimal absorption of lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid dispersion formulations (SDF) were developed, and the pharmacokinetics of two SDF variants were assessed in a randomized, o...

Descripción completa

Detalles Bibliográficos
Autores principales: Jain, Jay Prakash, Leong, F. Joel, Chen, Lan, Kalluri, Sampath, Koradia, Vishal, Stein, Daniel S., Wolf, Marie-Christine, Sunkara, Gangadhar, Kota, Jagannath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571342/
https://www.ncbi.nlm.nih.gov/pubmed/28630183
http://dx.doi.org/10.1128/AAC.00868-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571342/
https://www.ncbi.nlm.nih.gov/pubmed/28630183
http://dx.doi.org/10.1128/AAC.00868-17

Ejemplares similares