The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the Medicines for Malaria Venture (MMV) Malaria Box of candidate anti...

Descripción completa

Detalles Bibliográficos
Autores principales: Vallières, Cindy, Avery, Simon V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571370/
https://www.ncbi.nlm.nih.gov/pubmed/28652237
http://dx.doi.org/10.1128/AAC.00459-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571370/
https://www.ncbi.nlm.nih.gov/pubmed/28652237
http://dx.doi.org/10.1128/AAC.00459-17

Ejemplares similares