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Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage

BACKGROUND: Prior studies have demonstrated hyporesponsiveness to pneumococcal conjugate vaccines (PCVs) when administered in the presence of homologous carriage. This may be substantially more important in Africa where carriage prevalence is high. Deriving a correlate of protection (CoP) for carria...

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Detalles Bibliográficos
Autores principales: Ojal, John, Hammitt, Laura L., Gaitho, John, Scott, J. Anthony G., Goldblatt, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571437/
https://www.ncbi.nlm.nih.gov/pubmed/28739116
http://dx.doi.org/10.1016/j.vaccine.2017.05.088