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Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer

ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play a role in cell migration, ECM synthesis, stress-fiber assembly, and cell contraction. Increased ROCK expression has been reported in multiple pathological conditions, includ...

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Detalles Bibliográficos
Autores principales: Whatcott, Clifford J., Ng, Serina, Barrett, Michael T., Hostetter, Galen, Von Hoff, Daniel D., Han, Haiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571985/
https://www.ncbi.nlm.nih.gov/pubmed/28841710
http://dx.doi.org/10.1371/journal.pone.0183871