Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assay (CiPA) was proposed to improve prediction of TdP...

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Detalles Bibliográficos
Autores principales: Dutta, Sara, Chang, Kelly C., Beattie, Kylie A., Sheng, Jiansong, Tran, Phu N., Wu, Wendy W., Wu, Min, Strauss, David G., Colatsky, Thomas, Li, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572155/
https://www.ncbi.nlm.nih.gov/pubmed/28878692
http://dx.doi.org/10.3389/fphys.2017.00616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572155/
https://www.ncbi.nlm.nih.gov/pubmed/28878692
http://dx.doi.org/10.3389/fphys.2017.00616

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