The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells

CLN1 disease (OMIM #256730) is an early childhood ceroid-lipofuscinosis associated with mutated CLN1, whose product Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme involved in the removal of palmitate residues from S-acylated proteins. In neurons, PPT1 expression is also linked to syna...

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Detalles Bibliográficos
Autores principales: Pezzini, Francesco, Bianchi, Marzia, Benfatto, Salvatore, Griggio, Francesca, Doccini, Stefano, Carrozzo, Rosalba, Dapkunas, Arvydas, Delledonne, Massimo, Santorelli, Filippo M., Lalowski, Maciej M., Simonati, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572227/
https://www.ncbi.nlm.nih.gov/pubmed/28878621
http://dx.doi.org/10.3389/fnmol.2017.00266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572227/
https://www.ncbi.nlm.nih.gov/pubmed/28878621
http://dx.doi.org/10.3389/fnmol.2017.00266

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