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Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

Genome‐scale metabolic models (GEMs) are widely used to calculate metabolic phenotypes. They rely on defining a set of constraints, the most common of which is that the production of metabolites and/or growth are limited by the carbon source uptake rate. However, enzyme abundances and kinetics, whic...

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Detalles Bibliográficos
Autores principales: Sánchez, Benjamín J, Zhang, Cheng, Nilsson, Avlant, Lahtvee, Petri‐Jaan, Kerkhoven, Eduard J, Nielsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572397/
https://www.ncbi.nlm.nih.gov/pubmed/28779005
http://dx.doi.org/10.15252/msb.20167411