Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses

We performed an integrated analysis of drug chemical structures and drug-induced transcriptional responses. We demonstrated that a network representing three-dimensional structural similarities among 5452 compounds can be used to automatically group together drugs with similar scaffolds, physicochem...

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Detalles Bibliográficos
Autores principales: Sirci, Francesco, Napolitano, Francesco, Pisonero-Vaquero, Sandra, Carrella, Diego, Medina, Diego L., di Bernardo, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572457/
https://www.ncbi.nlm.nih.gov/pubmed/28861278
http://dx.doi.org/10.1038/s41540-017-0022-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572457/
https://www.ncbi.nlm.nih.gov/pubmed/28861278
http://dx.doi.org/10.1038/s41540-017-0022-3

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