Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme

Although catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of reaction chemistries in re-engineered native proteins has proved challenging. Wholesale modification of natural enzymes is potentially compromised by their intrinsic complexity, which often obscure...

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Detalles Bibliográficos
Autores principales: Watkins, Daniel W., Jenkins, Jonathan M. X., Grayson, Katie J., Wood, Nicola, Steventon, Jack W., Le Vay, Kristian K., Goodwin, Matthew I., Mullen, Anna S., Bailey, Henry J., Crump, Matthew P., MacMillan, Fraser, Mulholland, Adrian J., Cameron, Gus, Sessions, Richard B., Mann, Stephen, Anderson, J. L. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572459/
https://www.ncbi.nlm.nih.gov/pubmed/28842561
http://dx.doi.org/10.1038/s41467-017-00541-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572459/
https://www.ncbi.nlm.nih.gov/pubmed/28842561
http://dx.doi.org/10.1038/s41467-017-00541-4

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