Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes

Differentiation of certain cell types is followed by a downregulation of PARP1 expression. We show that the reduction in the abundance of PARP1 in hematopoietic progenitor cells and monocytes is tightly controlled by the cell cycle. The differentiation-associated cell cycle exit induces E2F1 replace...

Descripción completa

Detalles Bibliográficos
Autores principales: Wiśnik, Ewelina, Płoszaj, Tomasz, Robaszkiewicz, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572705/
https://www.ncbi.nlm.nih.gov/pubmed/28842672
http://dx.doi.org/10.1038/s41598-017-10307-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572705/
https://www.ncbi.nlm.nih.gov/pubmed/28842672
http://dx.doi.org/10.1038/s41598-017-10307-z

Ejemplares similares