Sost deficiency led to a greater cortical bone formation response to mechanical loading and altered gene expression

Bone adaptation optimizes mass and structure, but the mechano-response is already reduced at maturation. Downregulation of sclerostin was believed to be a mandatory step in mechano-adaptation, but in young mice it was shown that load-induced formation can occur independent of sclerostin, a product o...

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Detalles Bibliográficos
Autores principales: Pflanz, David, Birkhold, Annette I., Albiol, Laia, Thiele, Tobias, Julien, Catherine, Seliger, Anne, Thomson, Erin, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Kornak, Uwe, Checa, Sara, Willie, Bettina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572735/
https://www.ncbi.nlm.nih.gov/pubmed/28842678
http://dx.doi.org/10.1038/s41598-017-09653-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572735/
https://www.ncbi.nlm.nih.gov/pubmed/28842678
http://dx.doi.org/10.1038/s41598-017-09653-9

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