A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells

Retrovirus integration into the host genome relies on several host enzymes, potentially including DNA polymerase β (Pol β). However, whether human Pol β is essential for lentivirus replication in human cells is unclear. Here, we abolished DNA polymerase β (Pol β) expression by targeting its DNA poly...

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Detalles Bibliográficos
Autores principales: Goetze, Russell W., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572920/
https://www.ncbi.nlm.nih.gov/pubmed/28684413
http://dx.doi.org/10.1074/jbc.M117.793661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572920/
https://www.ncbi.nlm.nih.gov/pubmed/28684413
http://dx.doi.org/10.1074/jbc.M117.793661

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