Cargando…

Silica nanoparticles induce liver fibrosis via TGF-β(1)/Smad3 pathway in ICR mice

The liver is one of the target organs of silica nanoparticles (SiO(2) NPs) but the toxic mechanism on the liver still remains unclear. This study aimed to explore the hepatic toxicity and its mechanism through repeated intravenous exposure to SiO(2) NPs in ICR mice. Results indicated that SiO(2) NPs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Yang, Duan, Junchao, Li, Yang, Li, Yanbo, Jing, Li, Yang, Man, Wang, Ji, Sun, Zhiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573053/ https://www.ncbi.nlm.nih.gov/pubmed/28860765 http://dx.doi.org/10.2147/IJN.S132304

Ejemplares similares

Acute Toxicity of Amorphous Silica Nanoparticles in Intravenously Exposed ICR Mice
por: Yu, Yang, et al.
Publicado: (2013)

Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo
por: Yu, Yang, et al.
Publicado: (2019)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint
por: Duan, Junchao, et al.
Publicado: (2013)

The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
por: Dong, Xuemeng, et al.
Publicado: (2020)

Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice
por: Zhang, Dong, et al.
Publicado: (2017)

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling
por: Guo, Caixia, et al.
Publicado: (2016)

Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways
por: Lin, Liteng, et al.
Publicado: (2018)

Aspirin attenuates liver fibrosis by suppressing TGF-β1/Smad signaling
por: Sun, Yimin, et al.
Publicado: (2022)

Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway
por: Geng, Fei, et al.
Publicado: (2023)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling
por: Song, Yu, et al.
Publicado: (2023)

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
por: Hernández-Aquino, Erika, et al.
Publicado: (2017)

Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β1/Smad Signaling Pathway
por: Yuan, Xingxing, et al.
Publicado: (2018)

DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles
por: Zou, Yang, et al.
Publicado: (2016)

Oxidative Damage and Energy Metabolism Disorder Contribute to the Hemolytic Effect of Amorphous Silica Nanoparticles
por: Jiang, Lizhen, et al.
Publicado: (2016)

Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway
por: Cai, Fei-Fei, et al.
Publicado: (2018)

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro
por: Duan, Junchao, et al.
Publicado: (2018)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

P311 promotes renal fibrosis via TGFβ1/Smad signaling
por: Yao, Zhihui, et al.
Publicado: (2015)

let-7a suppresses liver fibrosis via TGFβ/SMAD signaling transduction pathway
por: Zhang, Yinghui, et al.
Publicado: (2019)

Astragaloside IV alleviates silica-induced pulmonary fibrosis via inactivation of the TGF-β1/Smad2/3 signaling pathway
por: Li, Nannan, et al.
Publicado: (2021)

Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1/Smads Signaling Pathway
por: Chen, Hongshu, et al.
Publicado: (2017)

Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments
por: Xiao, Liyan, et al.
Publicado: (2023)

Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats
por: Wang, Yi, et al.
Publicado: (2017)

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling
por: Guo, Caixia, et al.
Publicado: (2015)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

Liquiritigenin attenuates isoprenaline-induced myocardial fibrosis in mice through the TGF-β1/Smad2 and AKT/ERK signaling pathways
por: Li, Li, et al.
Publicado: (2021)

Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF-β1/Smad Signaling in Mice
por: Lu, Jing, et al.
Publicado: (2018)

ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice
por: Sun, Quan, et al.
Publicado: (2017)

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis
por: Duan, Junchao, et al.
Publicado: (2014)

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
por: Tang, Li-xia, et al.
Publicado: (2012)

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway
por: Yang, Fan, et al.
Publicado: (2020)

Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis
por: Yang, Yang, et al.
Publicado: (2021)

MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7
por: Zhou, Qian-Yang, et al.
Publicado: (2021)

Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
por: Wu, Shi-Pin, et al.
Publicado: (2017)

Inflammation–coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos
por: Duan, Junchao, et al.
Publicado: (2018)

Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice
por: Huang, Ping, et al.
Publicado: (2022)

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway
por: Zhou, Ling, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_thpltietekbul3v9he30meovb5