Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, I(f), in Mouse Sinoatrial Node Myocytes

Cardiac pacemaking, at rest and during the sympathetic fight-or-flight response, depends on cAMP (3′,5′-cyclic adenosine monophosphate) signaling in sinoatrial node myocytes (SAMs). The cardiac “funny current” (I(f)) is among the cAMP-sensitive effectors that drive pacemaking in SAMs. I(f) is produc...

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Detalles Bibliográficos
Autores principales: St. Clair, Joshua R., Larson, Eric D., Sharpe, Emily J., Liao, Zhandi, Proenza, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573264/
https://www.ncbi.nlm.nih.gov/pubmed/28868308
http://dx.doi.org/10.3390/jcdd4030010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573264/
https://www.ncbi.nlm.nih.gov/pubmed/28868308
http://dx.doi.org/10.3390/jcdd4030010

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