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Overexpression of miR-210 and its significance in ischemic tissue damage

Hypoxia-induced miR-210 displays a pro-survival, cytoprotective and pro-angiogenic role in several in vitro systems. In vivo, we previously found that miR-210 inhibition increases ischemic damage. Here we describe the generation of a versatile transgenic mouse model allowing the evaluation of miR-21...

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Detalles Bibliográficos
Autores principales: Zaccagnini, G., Maimone, B., Fuschi, P., Maselli, D., Spinetti, G., Gaetano, C., Martelli, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573334/
https://www.ncbi.nlm.nih.gov/pubmed/28842599
http://dx.doi.org/10.1038/s41598-017-09763-4