A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

Macrophage polarization plays an important role in tissue damage and repair. In this study, we show that Substance-P (SP) can directly induce M2 polarization of inflammatory macrophages. SP induced the differentiation of GM-CSF-differentiated pro-inflammatory macrophages into alternatively activated...

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Detalles Bibliográficos
Autores principales: Lim, Ji Eun, Chung, Eunkyung, Son, Youngsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573373/
https://www.ncbi.nlm.nih.gov/pubmed/28842601
http://dx.doi.org/10.1038/s41598-017-09639-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573373/
https://www.ncbi.nlm.nih.gov/pubmed/28842601
http://dx.doi.org/10.1038/s41598-017-09639-7

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