A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA

Genome integrity is continuously threatened by endogenous sources of DNA damage including reactive oxygen species (ROS) produced by cell metabolism. Factors of the RNA interference (RNAi) machinery have been recently involved in the cellular response to DNA damage (DDR) in proliferating cells. To in...

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Detalles Bibliográficos
Autores principales: Pignataro, Daniela, Francia, Sofia, Zanetta, Francesca, Brenna, Giulia, Brandini, Stefania, Olivieri, Anna, Torroni, Antonio, Biamonti, Giuseppe, Montecucco, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573376/
https://www.ncbi.nlm.nih.gov/pubmed/28842646
http://dx.doi.org/10.1038/s41598-017-09910-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573376/
https://www.ncbi.nlm.nih.gov/pubmed/28842646
http://dx.doi.org/10.1038/s41598-017-09910-x

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