The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A(2A) receptor controlling its cell surface expression and function in vivo

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson’s disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A(2A) receptor (A(2A)R) cell surface expression and function in vivo. In addition, we showed that GPR37 and A(2A)R do oligomerize...

Descripción completa

Detalles Bibliográficos
Autores principales: Morató, Xavier, Luján, Rafael, López-Cano, Marc, Gandía, Jorge, Stagljar, Igor, Watanabe, Masahiko, Cunha, Rodrigo A., Fernández-Dueñas, Víctor, Ciruela, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573386/
https://www.ncbi.nlm.nih.gov/pubmed/28842709
http://dx.doi.org/10.1038/s41598-017-10147-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573386/
https://www.ncbi.nlm.nih.gov/pubmed/28842709
http://dx.doi.org/10.1038/s41598-017-10147-x

Ejemplares similares