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Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage

Pepcan-12 (RVD-hemopressin; RVDPVNFKLLSH) is the major peptide of a family of endogenous peptide endocannabinoids (pepcans) shown to act as negative allosteric modulators (NAM) of cannabinoid CB1 receptors. Noradrenergic neurons have been identified to be a specific site of pepcan production. Howeve...

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Detalles Bibliográficos
Autores principales:	Petrucci, Vanessa, Chicca, Andrea, Glasmacher, Sandra, Paloczi, Janos, Cao, Zongxian, Pacher, Pal, Gertsch, Jürg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573408/ https://www.ncbi.nlm.nih.gov/pubmed/28842619 http://dx.doi.org/10.1038/s41598-017-09808-8

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