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REST, a master regulator of neurogenesis, evolved under strong positive selection in humans and in non human primates
The transcriptional repressor REST regulates many neuronal genes by binding RE1 motifs. About one third of human RE1s are recently evolved and specific to primates. As changes in the activity of a transcription factor reverberate on its downstream targets, we assessed whether REST displays fast evol...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573535/ https://www.ncbi.nlm.nih.gov/pubmed/28842657 http://dx.doi.org/10.1038/s41598-017-10245-w |