REST, a master regulator of neurogenesis, evolved under strong positive selection in humans and in non human primates

The transcriptional repressor REST regulates many neuronal genes by binding RE1 motifs. About one third of human RE1s are recently evolved and specific to primates. As changes in the activity of a transcription factor reverberate on its downstream targets, we assessed whether REST displays fast evol...

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Detalles Bibliográficos
Autores principales: Mozzi, Alessandra, Guerini, Franca Rosa, Forni, Diego, Costa, Andrea Saul, Nemni, Raffaello, Baglio, Francesca, Cabinio, Monia, Riva, Stefania, Pontremoli, Chiara, Clerici, Mario, Sironi, Manuela, Cagliani, Rachele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573535/
https://www.ncbi.nlm.nih.gov/pubmed/28842657
http://dx.doi.org/10.1038/s41598-017-10245-w

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