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Separating Thermodynamics from Kinetics—A New Understanding of the Transketolase Reaction

Transketolase catalyzes asymmetric C−C bond formation of two highly polar compounds. Over the last 30 years, the reaction has unanimously been described in literature as irreversible because of the concomitant release of CO(2) if using lithium hydroxypyruvate (LiHPA) as a substrate. Following the re...

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Detalles Bibliográficos
Autores principales: Marsden, Stefan R., Gjonaj, Lorina, Eustace, Stephen J., Hanefeld, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573996/
https://www.ncbi.nlm.nih.gov/pubmed/28919932
http://dx.doi.org/10.1002/cctc.201601649