Crystal Structure of the DFNKF Segment of Human Calcitonin Unveils Aromatic Interactions between Phenylalanines

Although intensively studied, the high‐resolution crystal structure of the peptide DFNKF, the core‐segment of human calcitonin, has never been described. Here we report how the use of iodination as a strategy to promote crystallisation and facilitate phase determination, allowed us to solve, for the...

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Detalles Bibliográficos
Autores principales: Bertolani, Arianna, Pizzi, Andrea, Pirrie, Lisa, Gazzera, Lara, Morra, Giulia, Meli, Massimiliano, Colombo, Giorgio, Genoni, Alessandro, Cavallo, Gabriella, Terraneo, Giancarlo, Metrangolo, Pierangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573999/
https://www.ncbi.nlm.nih.gov/pubmed/27806188
http://dx.doi.org/10.1002/chem.201604639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573999/
https://www.ncbi.nlm.nih.gov/pubmed/27806188
http://dx.doi.org/10.1002/chem.201604639

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