Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury

BACKGROUND: Seizure is a common complication for severe traumatic brain injury (TBI). Valproic acid (VPA) is a first-line antiepileptic drug, though its metabolism is affected by genetic polymorphisms and varies between individuals. The aim of this study was to investigate such association and to ex...

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Detalles Bibliográficos
Autores principales: Sun, Yirui, Yu, Jian, Yuan, Qiang, Wu, Xing, Wu, Xuehai, Hu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574127/
https://www.ncbi.nlm.nih.gov/pubmed/28841884
http://dx.doi.org/10.1186/s13049-017-0382-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574127/
https://www.ncbi.nlm.nih.gov/pubmed/28841884
http://dx.doi.org/10.1186/s13049-017-0382-0

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