Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?

BACKGROUND: Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the b...

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Detalles Bibliográficos
Autores principales: Li, Jian-Ming, Huang, Li-Ling, Liu, Fei, Tang, Bei-Sha, Yan, Xiao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574137/
https://www.ncbi.nlm.nih.gov/pubmed/28841840
http://dx.doi.org/10.1186/s12883-017-0942-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574137/
https://www.ncbi.nlm.nih.gov/pubmed/28841840
http://dx.doi.org/10.1186/s12883-017-0942-y

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