The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting

BACKGROUND: Patients with BRCA1-like tumors correlate with improved response to DNA double-strand break-inducing therapy. A gene expression-based classifier was developed to distinguish between BRCA1-like and non-BRCA1-like tumors. We hypothesized that these tumors may also be more sensitive to PARP...

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Detalles Bibliográficos
Autores principales: Severson, Tesa M., Wolf, Denise M., Yau, Christina, Peeters, Justine, Wehkam, Diederik, Schouten, Philip C., Chin, Suet-Feung, Majewski, Ian J., Michaut, Magali, Bosma, Astrid, Pereira, Bernard, Bismeijer, Tycho, Wessels, Lodewyk, Caldas, Carlos, Bernards, René, Simon, Iris M., Glas, Annuska M., Linn, Sabine, van ‘t Veer, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574249/
https://www.ncbi.nlm.nih.gov/pubmed/28851423
http://dx.doi.org/10.1186/s13058-017-0861-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574249/
https://www.ncbi.nlm.nih.gov/pubmed/28851423
http://dx.doi.org/10.1186/s13058-017-0861-2

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