Analgesia by deletion of spinal neurokinin 1 receptor expressing neurons using a bioengineered substance P-Pseudomonas exotoxin conjugate

Cell deletion approaches to pain directed at either the primary nociceptive afferents or second-order neurons are highly effective analgesic manipulations. Second-order spinal neurons expressing the neurokinin 1 (NK1) receptor are required for the perception of many types of pain. To delete NK1+ neu...

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Detalles Bibliográficos
Autores principales: Iadarola, Michael J, Sapio, Matthew R, Wang, Xunde, Carrero, Hector, Virata-Theimer, Maria Luisa, Sarnovsky, Robert, Mannes, Andrew J, FitzGerald, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574484/
https://www.ncbi.nlm.nih.gov/pubmed/28814145
http://dx.doi.org/10.1177/1744806917727657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574484/
https://www.ncbi.nlm.nih.gov/pubmed/28814145
http://dx.doi.org/10.1177/1744806917727657

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