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Early-onset behavioral and neurochemical deficits in the genetic mouse model of phenylketonuria
Phenylketonuria (PKU) is one of the most common human inborn errors of metabolism, caused by phenylalanine hydroxylase deficiency, leading to high phenylalanine and low tyrosine levels in blood and brain causing profound cognitive disability, if untreated. Since 1960, population is screened for hype...
Autores principales: | Fiori, Elena, Oddi, Diego, Ventura, Rossella, Colamartino, Marco, Valzania, Alessandro, D’Amato, Francesca Romana, Bruinenberg, Vibeke, van der Zee, Eddy, Puglisi-Allegra, Stefano, Pascucci, Tiziana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574541/ https://www.ncbi.nlm.nih.gov/pubmed/28850618 http://dx.doi.org/10.1371/journal.pone.0183430 |
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