AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells

BACKGROUND: The At-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancers (GCs) with a poor prognosis. Growing evidence indicates that loss of ARID1A expression leads to activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway by AKT phosphorylation. We aim to investi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Dakeun, Yu, Eun Ji, Ham, In-Hye, Hur, Hoon, Kim, You-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574587/
https://www.ncbi.nlm.nih.gov/pubmed/28860825
http://dx.doi.org/10.2147/OTT.S139664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574587/
https://www.ncbi.nlm.nih.gov/pubmed/28860825
http://dx.doi.org/10.2147/OTT.S139664

Ejemplares similares