Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma

Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or aberrant subcellular distribution of Ape1 has been detected in many cancer types, correlated with drug response, tumor prognosis, or patient surv...

Descripción completa

Detalles Bibliográficos
Autores principales: Ströbel, Thomas, Madlener, Sibylle, Tuna, Serkan, Vose, Sarah, Lagerweij, Tonny, Wurdinger, Thomas, Vierlinger, Klemens, Wöhrer, Adelheid, Price, Brendan D., Demple, Bruce, Saydam, Okay, Saydam, Nurten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574897/
https://www.ncbi.nlm.nih.gov/pubmed/28852018
http://dx.doi.org/10.1038/s41598-017-10013-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574897/
https://www.ncbi.nlm.nih.gov/pubmed/28852018
http://dx.doi.org/10.1038/s41598-017-10013-w

Ejemplares similares