Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma

Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key factor in base-excision repair of DNA. High expression or aberrant subcellular distribution of Ape1 has been detected in many cancer types, correlated with drug response, tumor prognosis, or patient surv...

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Detalles Bibliográficos
Autores principales: Ströbel, Thomas, Madlener, Sibylle, Tuna, Serkan, Vose, Sarah, Lagerweij, Tonny, Wurdinger, Thomas, Vierlinger, Klemens, Wöhrer, Adelheid, Price, Brendan D., Demple, Bruce, Saydam, Okay, Saydam, Nurten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574897/
https://www.ncbi.nlm.nih.gov/pubmed/28852018
http://dx.doi.org/10.1038/s41598-017-10013-w

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